The district includes parts of southern Brooklyn and south and central Queens. In Queens, it includes the neighborhoods of Forest Hills, Maspeth, Fresh Meadows, Glendale, Howard Beach, Kew Gardens, Kew Gardens Hills, Middle Village, Ozone Park, Rego Park, Rockaway Beach, and Woodhaven. In Brooklyn, it includes the neighborhoods Gerritsen Beach, Marine Park, Midwood, Mill Basin, and Sheepshead Bay.
In the 1998 U.S. House election, Weiner ran against Republican Louis Telano for the seat being vacated by Charles Schumer, who was running for the Senate seat held by Al D'Amato. Weiner defeated Telano by a margin of 66%–23%. He was re-elected in 2000, 2002, 2004, 2006, 2008, and 2010 never receiving less than 59% of the vote. In the House, he is a member of the Committee on Energy and Commerce. He was an unsuccessful candidate for Mayor of New York City in the 2005 Mayoral election. A graduate of State University of New York at Plattsburgh (SUNY), Weiner was an aide to then-U.S. Representative Schumer (1985–91). He was a member of the New York City Council (1992–98).